Strategies for the synthesis of brevipolides

• Yudhi D. Kurniawan and
• A'liyatur Rosyidah

Beilstein J. Org. Chem. 2021, 17, 2399–2416, doi:10.3762/bjoc.17.157

• , brevipolides G–I (7–9) were found to inhibit the CCR5 receptor signaling as measured by a calcium mobilization assay with IC50 values of 15.5, 13.7, and 18.0 μM, respectively, which make them potential agents for treating HIV disease (Table 2, entries 7–9) [11]. Giménez and co-workers, in 2019, reported the

Synthesis of cyclic N¹-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells

• Ahmed Mahal,
• Stefano D’Errico,
• Nicola Borbone,
• Brunella Pinto,
• Agnese Secondo,
• Valeria Costantino,
• Valentina Tedeschi,
• Giorgia Oliviero,
• Vincenzo Piccialli and
• Gennaro Piccialli

Beilstein J. Org. Chem. 2015, 11, 2689–2695, doi:10.3762/bjoc.11.289

• neuronal cells. Keywords: calcium mobilization; cIDPR analogues; cyclic ADP-ribose (cADPR); cyclization; Introduction Nucleosides and nucleotides (NNs) are widely used as key intermediates and important core structures in the field of synthetic medicinal chemistry [1][2]. They represent versatile